PUBLICATIONS OF THE U904 (2008-2016)
PUBLICATIONS OF THE U1233 (2017-to date)

2008

Brancorsini, S., Davidson, I., and Sassone-Corsi, P. (2008) TIPT, a male germ cell-specific partner of TRF2, is chromatin-associated and interacts with HP1. Cell Cycle 7, 1415-22.

Nakahata, Y., Kaluzova, M., Grimaldi, B., Sahar, S., Hirayama, J., Chen, D., Guarente, L.P., and Sassone-Corsi, P. (2008) The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control. Cell. 134, 329-40.

Mishra, D.P. and Sassone-Corsi, P. (2008) Epigenetic control in male germ cells: a transillumination-assisted microdissection method for the analysis of developmentally regulated events. Methods Mol Biol. 450:119-26.

Nair, M., Nagamori, I., Sun, P., Prasad Mishra, D., Rhéaume, C., Li, B., Sassone-Corsi, P., and Dai, X. (2008) Nuclear regulator Pygo2 controls spermiogenesis and histone H3 acetylation. Developmental Biology. 320:446-455.

Acimovic, J., Fink, M., Pompon, D.,Bjorkhem, I., Hirayama, J., Sassone-Corsi, P., Golicnik, M., and Rozman, D. (2008) CREM modulates the circadian expression of CYP51, HMGCR, and cholesterogenesis in the liver. Biochem. Biophy. Res. Commun. 376:206-10.

Sassone-Corsi, P. (2008) Spotlight on Germ Cells: Stem cells of the germline: the specialized facets of their differentiation program. Cell Cycle. 7:3491-2.

Nagamori, I., Sassone-Corsi, P.(2008) Spotlight on Germ Cells: The chromatoid body of male germ cells: epigenetic control and miRNA pathway. Cell Cycle 7: 3503-8.

Borrelli, E., Nestler, E. J., Allis, C. D., and Sassone-Corsi, P. (2008) Decoding the Epigenetic Language of neuronal Plasticity. Neuron 60:961-74.

Tirotta E, Fontaine V, Picetti R, Lombardi M, Samad TA, Oulad-Abdelghani M, Edwards R, Borrelli E (2008) Signaling by dopamine regulates D2 receptors trafficking at the membrane. Cell Cycle 7:2241-2248.

2009

Bertolino A., Fazio L., Di Giorgio A., Blasi G., Romano R., Taurisano R., Caforio G., Sinibaldi L., Urini G., Popolizio T., Tirotta E., Papp A., Dallapiccola B., Borrelli E., Sadee W Genetically determined interaction between the dopamine transporter and the D2 receptor on prefronto-striatal activity and grey matter. J Neurosci. (2009) 29:1224-1234.

Grimaldi, B., Nakahata, Y., Kaluzova, M., Masubuchi, S., and Sassone-Corsi, P. (2009) Chromatin remodeling, metabolism and circadian clocks: the interplay of CLOCK and SIRT1. Int. J. Biochem. Cell Biol. 41, 81-86.

Madan, V., Madan, B., Brykczynska, U., Zilbermann, F., Hogeveen, K., Döhner, K., Döhner, H., Weber, O., Blum, C., Rodewald, H.R., Sassone-Corsi, P., Peters, A.H.F.M., and Fehling, H.J. (2009) Impaired function of primitive hematopoietic cells in mice lacking the Mixed-Lineage-Leukemia homolog Mll5. Blood. 113:1444-54.

Kolthur-Seetharam, U., Teerds, K., de Rooij, D.G., Wendling, O., McBurney, M., Sassone-Corsi, P., and Davidson, I. (2009) The histone deacetylase SIRT1 controls male fertility in mice through regulation of hypothalamic-pituitary gonadotropin signaling. Biol Reprod. 80:384-91.

Nakahata, Y., Sahar, S., Astarita, G., Kaluzova, M., and Sassone-Corsi, P. (2009) Circadian Control of the NAD+Salvage Pathway by CLOCK-SIRT1. Science 324:654-7.

Tamaru, T., Hirayama, J., Isojima, Y., Nagai, K., Norioka, S., Takamatsu, K., and Sassone-Corsi, P. (2009) CK2aphosphorylates BMAL1 to regulate the mammalian clock. Nature Struct. Mol. Biol. 16:446-8.

Masubuchi, S. and Sassone-Corsi, P. (2009) Circadian biology: an unexpected invitee to new time zones. Curr Biol.19:R298-300.

Sassone-Corsi, P. (2009) SIRT1/PARP-1 functional interplay. Cell Cycle. 8:1649.

Ohe, K., Tamai, K.T., Parvinen, M., and Sassone-Corsi, P. (2009) DAX-1 and SOX6 molecular interplay results in an antagonistic effect in pre-mRNA splicing. Dev Dyn. 238:1595-604.

El Ramy, R., Magroun, N., Messadecq, N., Gauthier, L.R., Boussin, F.D., Kolthur-Seetharam, U., Schreiber, V., McBurney, M.W., Sassone-Corsi, P., and Dantzer, F. (2009) Functional interplay between Parp-1 and SirT1 in genome integrity and chromatin-based processes. Cell. Mol. Life Sci. 66:3219-34.

Hirayama, J., Miyamura, N., Uchida, Y., Asaoka, Y., Honda, R., Sawanobori, K., Todo, T., Yamamoto, T., Sassone-Corsi, P.,and Nishina, H. (2009) Common light signaling pathways controlling DNA repair and circadian clock entrainment in zebrafish. Cell Cycle 8:2794-801.

Eckel-Mahan, K. and Sassone-Corsi, P. (2009) Metabolism control by the circadian clock and vice versa. (2009) Nat Struct Mol Biol. 16:462-7.

Sahar, S. and Sassone-Corsi, P. (2009) Metabolism and Cancer:  The circadian clock connection. Nature Reviews Cancer. 9:886-96.

Lardenois, A., Chalmel, F., Demougin, P., Kotaja, N., Sassone-Corsi, P., Primig, M. (2009) Fhl5/Act, a CREM-binding transcriptional activator required for normal sperm maturation and morphology, is not essential for testicular gene expression. Reprod Biol Endocrinol. 7:133.

2010

Sahar, S., Zocchi, L., Kinoshita, C., Borrelli, E., Sassone-Corsi, P.(2010) Regulation of BMAL1 protein stability and circadian function by GSK3beta-mediated phosphorylation. PLoS One. 1;5(1)

Masubuchi, S., Gao, T., O’Neill, A., Eckel-Mahan, K., Newton, A.C., Sassone-Corsi, P. (2010) Protein phosphatase PHLPP1 controls the light-induced resetting of the circadian clock. Proc Natl Acad Sci USA. 107(4):1642-7.

Eckel-Mahan, K. and Sassone-Corsi, P. (2010) Blood pressure AsSAuLTed by the circadian clock. Cell Metab. 11(2):97-9.

Zocchi, L. and Sassone-Corsi, P. (2010) Joining the dots: from chromatin remodeling to neuronal plasticity. Curr Opin Neurobiol. 20(4):432-440.

Eckel-Mahan, K. and Sassone-Corsi, P. (2010) Aging brains and waning clocks on the process of habituation. Aging (Albany NY). (6):320-1.

Blagosklonny, M. V., Campisi, J., Sinclair, D. A., Bartke, A., Blasco, M. A., Bonner, W. M., Bohr, V. A., Brosh, R. M. Jr., Brunet, A., Depinho, R. A., Donehower, L. A., Finch, C. E., Finkel, T., Gorospe, M., Gudkov, A. V., Hall, M. N., Hekimi, S., Helfand, S. L., Karlseder, J., Kenyon, C., Kroemer, G., Longo, V., Nussenzweig, A., Osiewacz, H. D., Peeper, D. S., Rando, T. A., Rudolph, K. L., Sassone-Corsi, P.,Serrano, M., Sharpless, N. E., Skulachev, V. P., Tilly, J. L., Tower, J., Verdin, E., Vijg, J. (2010) Impact papers on aging in 2009. Aging (Albany NY). 2:111-21.

Masri, S. and Sassone-Corsi, P. (2010) Plasticity and Specificity of the Circadian Epigenome. Nature Neuroscience 13, 1324-9.

Katada, S. and Sassone-Corsi, P. (2010) The histone methyltransferase MLL1 permits the oscillation of circadian gene expression. Nature Struct. Mol. Biol. 17, 1414-21.

Grimaldi, B., Bellet, M. M., Katada, S., Astarita, G., Hirayama, J., Amin, R. H., Granneman, J. G., Piomelli, D., Leff, T., Sassone-Corsi. P. (2010) PER2 controls lipid metabolism by direct regulation of PPAR. Cell Metab. 12:509-20.

Bellet, M. M. and Sassone-Corsi, P. (2010) Mammalian circadian clock and metabolism – the epigenetic link. J Cell Sci. 123:3837-48.

Hatanaka, F., Matsubara, C., Myung, J., Yoritaka, T., Kamimura, N., Tsutsumi, S., Kanai, A., Suzuki, Y., Sassone-Corsi, P., Aburatani, H., Sugano, S., Takumi, T. (2010) Genome-wide profiling of the core clock protein BMAL1 targets reveals a strict relationship with metabolism. Mol Cell Biol. 30:5636-48.  

Sassone-Corsi, P. (2010) Commentary: the year in circadian rhythms. Mol Endocrinol. 24:2081-7.

Martianov, I., Choukrallah, M. A., Krebs, A., Ye, T., Legras, S., Rijkers, E., Van Ijcken, W., Jost, B., Sassone-Corsi, P., Davidson, I. (2010) Cell-specific occupancy of an extended repertoire of CREM and CREB binding loci in male germ cells. BMC Genomics. 11:530.

Sahar S, Zocchi L, Kinoshita C, Borrelli E, Sassone-Corsi P. Regulation of BMAL1 protein stability and circadian function by GSK3beta-mediated phosphorylation. PLoS One. 5:e856.

Tripathi PP, Santorufo G, Brilli E, Borrelli E, Bozzi Y. Kainic acid-induced seizures activate GSK-3beta in the hippocampus of D2R-/- mice. Neuroreport. (2010) 21:846-50.

2011

Benoit-Marand M., Ballion B., Borrelli E., Boraud T., Gonon F. Inhibition of dopamine uptake by D2 antagonists: an in vivo study. J. Neurochem. (2011) 116:449-58.

Fulton S, Thibault D, Mendez JA, Lahaie N, Tirotta E, Borrelli E, Bouvier M, Tempel BL, Trudeau LE. Contribution of Kv1.2 Voltage-gated Potassium channel to D2 autoreceptor regulation of axonal dopamine overflow. J. Biol. Chem. (2011) 286: 9360-72

Doretto S, Malerba M, Ramos M, Ikrar T, Kinoshita C, De Mei C, Tirotta E, Xu X, Borrelli E. Oligodendrocytes as regulators of neuronal networks during early postnatal development. PLoS One. (2011) 6:e19849.

Park E, Iaccarino C, Lee J, Kwon I, Baik SM, Kim M, Seong JY, Son GH, Borrelli E, Kim K. Regulatory roles of hnRNP M and Nova-1 in the alternative splicing of the dopamine D2 receptor pre-mRNA. J. Biol. Chem. (2011) 286:25301-8.

Zhu, C., Solorzano, C., Sahar, S., Realini, N., Fung, E., Sassone-Corsi, P., Piomelli, D. (2011) Proinflammatory stimuli control N-Acylphosphatidylethanolamine-specific phospholipase D expression in macrophages. Mol Pharmacol. 79:786-92.

Bellet, M. M., Vawter, M. P., Bunney, B. G., Bunney, W. E., Sassone-Corsi, P. (2011) Ketamine influences CLOCK:BMAL1 function leading to altered circadian gene expression. PLoS One. 6:e23982.

Sahar, S., Nin, V., Barbosa, M. T., Chini, E. N., Sassone-Corsi, P.(2011) Altered behavioral and metabolic circadian rhythms in mice with disrupted NAD+ oscillation. Aging. 3:794-802.

Voronina, E., Seydoux, G., Sassone-Corsi, P., Nagamori, I. (2011) RNA granules in germ cells. Cold Spring Harb Perspect Biol. 3(12). pii: a002774.

Aguilar-Arnal, L. and Sassone-Corsi, P. (2011) Stem cells: the clock within. Nature. 480:185-7.

Nagamori, I., Cruickshank, V. A., Sassone-Corsi, P. (2011) Regulation of an RNA granule during spermatogenesis: acetylation of MVH in the chromatoid body of germ cells. J Cell Sci. 124(Pt 24):4346-55.

Bellet, M. M., Orozco-Solis, R., Sahar, S., Eckel-Mahan, K., Sassone-Corsi, P. (2011) The time of metabolism: NAD+, SIRT1, and the circadian clock. Cold Spring Harb Symp Quant Biol. 76:31-8.

2012

Sahar, S. and Sassone-Corsi, P. (2012) Regulation of metabolism: the circadian clock dictates the time. Trends Endocrinol Metab. 23:1-8.

Sassone-Corsi, P. (2012) Minireview: NAD+, a circadian metabolite with an epigenetic twist. Endocrinology. 153:1-5.

Mora, E., Guglielmotti, A., Biondi, G., Sassone-Corsi, P. (2012) Bindarit: an anti-inflammatory small molecule that modulates the NF B pathway. Cell Cycle. 11:159-69.

Katada, S., Imhof, A., Sassone-Corsi, P. (2012) Connecting threads: epigenetics and metabolism. Cell. 148:24-8.

Kosir, R., Juvan, P., Perse, M., Budefeld, T., Majdic, G., Fink, M., Sassone-Corsi, P., Rozman, D. (2012) Novel insights into the downstream pathways and targets controlled by transcription factors CREM in the testis. PLoS One. 7:e31798.

Sahar, S. and Sassone-Corsi, P. (2012) Circadian rhythms and memory formation: regulation by chromatin remodeling. Front Mol Neurosci. 5:37.

Eckel-Mahan, K. L., Patel, V. R., Mohney, R. P., Vignola, K. S., Baldi, P., Sassone-Corsi, P.(2012) Coordination of the transcriptome and metabolome by the circadian clock. Proc Natl Acad Sci USA. 109:5541-6.

Zocchi, L. and Sassone-Corsi, P. (2012) SIRT1-mediated deacetylation of MeCP2 contributes to BDNF expression. Epigenetics. 7:695-700.

Patel, V. R., Eckel-Mahan, K., Sassone-Corsi, P., Baldi, P. (2012) CircadiOmics: integrating circadian genomics, transcriptomics, proteomics and metabolomics. Nat Methods. 9:772-73.

Masri, S., Zocchi, L., Katada, S., Mora, E., Sassone-Corsi,P. (2012) The circadian clock transcriptional complex: metabolic feedback intersects with epigenetic control. Ann NY Acad Sci. 1264:103-9. .

Peruquetti, R. L., de Mateo, S., Sassone-Corsi, P. (2012) Circadian proteins CLOCK and BMAL1 in the chromatoid body, a RNA processing granule of male germ cells. PLoS One. 7:e42695.

Bellet, M. M., Zocchi, L., Sassone-Corsi, P. (2012) The RelB subunit of NFκB acts as a negative regulator of circadian gene expression. Cell Cycle. 11:3304-11.

Sharpley, M. S., Marciniak, C., Eckel-Mahan, K., McManus, M., Crimi, M., Waymire, K., Lin, C. S., Masubuchi, S., Friend, N., Koike, M., Chalkia, D., MacGregor, G., Sassone-Corsi, P., Wallace, D. C. (2012) Heteroplasmy of mouse mtDNA is genetically unstable and results in altered behavior and cognition. Cell. 151:333-43.

Masri, S. and Sassone-Corsi, P. (2012) The circadian clock: a framework linking metabolism, epigenetics and neuronal function. Nat Rev Neurosci. 14:69-75.

Sassone-Corsi, P. (2012) The cyclic AMP pathway. Cold Spring Harb Perspect Biol. 4(12). pii: a011148.

Anzalone, A., Lizardi-Ortiz, J.E., Ramos, M., De Mei, C., Hopf, F.W., Iaccarino, C., Halbout, B., Jacobsen, J., Kinoshita, C., Welter, M., Caron, M.G., Bonci, A., Sulzer, D., Borrelli, E. Dual control of dopamine synthesis and release by pre- and postsynaptic dopamine D2 receptors. J. Neurosci. (2012) 32:9023-9034.

Maheux, J., St-Hilaire, M., Voyer, D., Tirotta, E., Borrelli, E., Rouillard, C., Rompré, P.P., Lévesque D. Dopamine (D2) antagonist-induced striatal Nurr77 expression requires activation of mGlu5 receptors by cortical afferents. Front Pharmacol. (2012) 3:153 

2013

Radl,D., De Mei, C., Chen, E., Lee, H., Borrelli, E. Each individual isoform of the dopamine D2 receptor protects from lactotroph hyperplasia. (2013) Mol. Endocrinol. 27(6): 953-65

Viaro R, Calcagno M, Marti M, Borrelli E, Morari M. Pharmacological and genetic evidence for pre- and postsynaptic D2 receptor involvement in motor responses to nociception/orphanin FQ receptor ligands. Neuropharmacology. (2013) 72:126-38.

Upadhyay SK, Eckel-Mahan KL, Mirbolooki MR, Tjong I, Griffey SM, Schmunk G, Koehne A,   Halbout B, Iadonato S, Pedersen B, Borrelli E, Wang PH, Mukherjee J, Sassone-Corsi P, Chandy    KG. Selective Kv1.3 channel blocker as therapeutic for obesity and insulin resistance. Proc Natl Acad Sci USA. (2013) 110:E2239-48.

Zhang Y, Wang C, Wang L, Parks GS, Zhang X, Guo Z, Ke Y, Li KW, Kim MK, Vo B, Borrelli E, Ge G, Yang L, Wang Z, Garcia-Fuster MJ, Luo ZD, Liang X, Civelli O. A novel analgesic isolated from a traditional chinese medicine. Curr. Biol.(2013) pii: S0960-9822 (13) 01494-2.

Eckel-Mahan, K. and Sassone-Corsi, P. (2013) Metabolism and the circadian clock converge. Physiol Rev. 93:107-35.

Sassone-Corsi, P. (2013) Physiology. When metabolism and epigenetics converge. Science. 339:148-50.

Bellet, M. M., Nakahata, Y., Boudjelal, M., Watts, E., Mossakowska, D. E., Edwards, K. A., Cervantes, M., Astarita, G., Loh, C., Ellis, J. L., Vlasuk, G. P., Sassone-Corsi, P.(2013) Pharmacological modulation of circadian rhythms by synthetic activators of the deacetylase SIRT1. Proc Natl Acad Sci USA. 110:3333-8.

Masri, S., Patel, V. R., Eckel-Mahan, K. L., Peleg, S., Forne, I., Ladurner, A. G., Baldi, P., Imhof, A., Sassone-Corsi, P. (2013) Circadian acetylome reveals regulation of mitochondrial metabolic pathways. Proc Natl Acad Sci USA. 110:3339-44.

Aguilar-Arnal, L. and Sassone-Corsi, P.(2013) The circadian epigenome: how metabolism talks to chromatin remodeling. Curr Opin Cell Biol. 25:170-6.

Egg, M., Köblitz, L., Hirayama, J., Schwerte, T., Folterbauer, C., Kurz, A., Fiechtner, B., Möst, M., Salvenmoser, W., Sassone-Corsi, P., Pelster, B. (2013) Linking oxygen to time: the bidirectional interaction between the hypoxic signaling pathway and the circadian clock. Chronobiol Int. 30:510-29.

Zmrzljak, U., Korencic, A., Kosir, R., Golicnik, M., Sassone-Corsi, P., Rozman, D. (2013) Inducible cAMP early repressor regulates the Period 1 gene of the hepatic and adrenal clocks. J Biol Chem. 288:10318-27.

Sahar, S. and Sassone-Corsi, P. (2013) The epigenetic language of circadian clocks. Handb Exp Pharmacol. 217:29-44.

Tian, X., Zhang, S., Liu, H. M., Zhang, Y. B., Blair, C. A., Mercola, D., Sassone-Corsi, P., Zi, X. (2013) Histone lysine-specific methyltransferases and demethylases in carcinogenesis: new targets for cancer therapy and prevention. Curr Cancer Drug Targets. 13:558-79.

Bellet, M. M., Deriu, E., Liu, J. Z., Grimaldi, B., Blaschitz, C., Zeller, M., Edwards, R. A., Sahar, S., Dandekar, S., Baldi, P., George, M. D., Raffatellu, M., Sassone-Corsi, P. (2013) Circadian clock regulates the host response to Salmonella. Proc Natl Acad Sci USA. 110:9897-902.

Upadhyay, S. K., Eckel-Mahan, K. L., Mirbolooki, M. R., Tjong, I., Griffey, S. M., Schmunk, G., Koehne, A., Halbout, B., Iadonato, S., Pedersen, B., Borrelli, E., Wang, P. H., Mukherjee, J., Sassone-Corsi, P.,Chandy, K. G. (2013) Selective Kv1.3 channel blocker as therapeutic for obesity and insulin resistance. Proc Natl Acad Sci USA. 110:E2239-48.

Baeza-Raja, B., Eckel-Mahan, K., Zhang, L., Vagena, E., Tsigelny, I. F., Sassone-Corsi, P., Ptácek, L. J., Akassoglou, K. (2013) p75 neurotrophin receptor is a clock gene that regulates oscillatory components of circadian and metabolic networks. J Neurosci. 33:10221-34.

Eckel-Mahan, K. and Sassone-Corsi, P. (2013) Epigenetic regulation of the molecular clockwork. Prog Mol Biol Transl Sci. 119:29-50.

Masri, S., Cervantes, M., Sassone-Corsi, P. (2013) The circadian clock and cell cycle: interconnected biological circuits. Curr Opin Cell Biol. 25:730-4.

Aguilar-Arnal, L., Hakim, O., Patel, V. R., Baldi, P., Hager, G. H., Sassone-Corsi, P. (2013) Cycles in spatial and temporal chromosomal organization driven by the circadian clock. Nat Struct Mol Biol. 20:1206-13.

Dyar, K. A., Ciciliot, S., Wright, L. E., Biensø, R. S., Tagliazucchi, G. M., Patel, V. R., Forcato, M., Paz, M. I., Gudiksen, A., Solagna, F., Albiero, M., Moretti, I., Eckel-Mahan, K. L., Baldi, P.,Sassone-Corsi, P., Rizzuto, R., Bicciato, S., Pilegaard, H., Blaauw, B., Schiaffino, S. (2013) Muscle insulin sensitivity and glucose metabolism are controlled by the intrinsic muscle clock.

Tamaru, T., Hattori, M., Ninomiya, Y., Kawamura, G., Varès, G., Honda, K., Mishra, D. P., Wang, B., Benjamin, I., Sassone-Corsi, P., Ozawa, T., Takamatsu, K. (2013) ROS stress resets circadian clocks to coordinate pro-survival signals. PLoS One. 8:e82006.

Eckel-Mahan, K., Patel, V., de Mateo, S., Orozco-Solis, R., Ceglia, N., Sahar, S., Dilag, S., Dyar, K., Baldi, P., Sassone-Corsi, P.(2013) Reprogramming of the circadian clock by nutritional challenge. Cell. 155:1464-78.

2014

Brami-Cherrier, K., Anzalone, A., Ramos, M., Forne, I., Macciardi, F., Imhof, A., Borrelli, E. Epigenetic reprogramming of cortical neurons through alteration of dopaminergic circuits. Mol. Psychiatry (2014) 19(11):1193-200.

Brami-Cherrier, K., Anzalone, A., Ramos, M., Forne, I., Macciardi, F., Imhof, A., Borrelli, E. Ablation of D2 autoreceptors causes epigenetic reprogramming of cortical neurons. Mol. Psychiatry(2014) 19(11):1153.

Sahar, S., Masubuchi, S., Eckel-Mahan, K., Vollmer, S., Galla, L., Ceglia, N., Masri, S., Barth, T. K., Grimaldi, B., Oluyemi, O., Astarita, G., Hallows, W. C., Piomelli, D., Imhof, A., Baldi, P., Denu, J. M., Sassone-Corsi, P. (2014) Circadian control of fatty acid elongation by SIRT1-mediated deacetylation of acetyl-CoA synthetase 1. J Biol Chem. 289:6091-7.

Orozco-Solis, R. and Sassone-Corsi, P. (2014) Epigenetic control and the circadian clock: linking metabolism to neuronal responses. Neuroscience. 264C:76-87.

Curtis, A. M., Bellet, M. M., Sassone-Corsi, P., O’Neill, L. A. (2014) Circadian clock proteins and immunity. Immunity. 40:178-186.

de Mateo, S. and Sassone-Corsi, P. (2014) Regulation of spermatogenesis by small non-coding RNAs: role of the germ granule. Semin Cell Dev Biol. 29:84-92.

Patel, V. R., Eckel-Mahan, K., Sassone-Corsi, P., Baldi, P. (2014) How pervasive are circadian oscillations? Trends Cell Biol. 24:329-31.

Orozco-Solis, R. and Sassone-Corsi, P. (2014) Circadian clock: linking epigenetics to aging. Curr Opin Genet Dev. 26C:66-72.

Masri, S., Rigor, P., Cervantes, M., Ceglia, N., Sebastian, C., Xiao, C., Roqueta-Rivera, M., Deng, C., Osborne, T. F., Mostoslavsky, R., Baldi, P., Sassone-Corsi, P. (2014) Partitioning circadian transcription by SIRT6 leads to segregated control of cellular metabolism. Cell. 158:659-672.

Bell, E. L., Nagamori, I., Williams, E. O., Del Rosario, A. M., Bryson, B. D., Watson, N., White, F. M., Sassone-Corsi, P.,Guarente, L. (2014) SirT1 is required in the male germ cell for differentiation and fecundity in mice. Development. 141:3495-504.

Wu, C., Sui, G., Archer, S. N., Sassone-Corsi, P.,Aitken, K., Bagli, D., Chen, Y. (2014) Local receptors as novel regulators for peripheral clock expression. FASEB J. 28:4610-6.

Masri, S. and Sassone-Corsi, P. (2014) Sirtuins and the circadian clock: Bridging chromatin and metabolism. Sci Signal. 7:re6.

Sassone-Corsi, P. (2014) The time of your life. Cerebrum Collection

Aguilar-Arnal, L. and Sassone-Corsi, P. (2014) Chromatin landscape and circadian dynamics: Spatial and temporal organization of clock transcription. pii: 201411264. Proc Natl Acad Sci USA. 112:6863-70.

2015

Masri, S., Kinouchi, K., Sassone-Corsi, P. (2015) Circadian clocks, epigenetics, and cancer. Curr Opin Oncol. 27:50-6.

Aguilar-Arnal, L. and Sassone-Corsi, P. (2015) Chromatin dynamics of circadian transcription. Curr Mol Bio Rep. 1:1-9.

Aguilar-Arnal, L., Katada, S., Orozco-Solis, R., Sassone-Corsi, P. (2015) NAD+-SIRT1 control of H3K4 trimethylation through circadian deacetylation of MLL1. Nat Struct Mol Biol. 22:312-8.

Orozco-Solis, R., Ramadori, G., Coppari, R., Sassone-Corsi, P. (2015) SIRT1 relays nutritional inputs to the circadian clock through the Sf1 neurons of the ventromedial hypothalamus. Endocrinology. 156:2174-84.

Asher, G. and Sassone-Corsi, P. (2015) Time for food: the intimate interplay between nutrition, metabolism, and the circadian clock. Cell. 161:84-92.

Patel, V. R., Ceglia, N., Zeller, M., Eckel-Mahan, K., Sassone-Corsi, P., Baldi, P. (2015) The pervasiveness and plasticity of circadian oscillations: the coupled circadian-oscillators framework. Bioinformatics. 31:3181-8.

Eckel-Mahan, K., Sassone-Corsi, P. (2015) Phenotyping circadian rhythms in mice. Curr Protoc Mouse Biol. 5:271-81.

Masri, S., Orozco-Solis, R., Aguilar-Arnal, L., Cervantes, M., Sassone-Corsi, P. (2015) Coupling circadian rhythms of metabolism and chromatin remodelling. Diabetes Obes Metab. 17(Suppl 1):17-22.

Tamaru, T., Hattori, M., Honda, K., Nakahata, Y., Sassone-Corsi, P., van der Horst, G. T., Ozawa, T., Takamatsu, K. (2015) CRY drives cyclic CK2-mediated BMAL1 phosphorylation to control the mammalian circadian clock. PLoS Biol.13:e1002293.

Arble, D. M., Bass, J., Behn, C. D., Butler, M. P., Challet, E., Czeisler, C., Depner, C. M., Elmquist, J., Franken, P., Grandner, M. A., Hanlon, E. C., Keene, A. C., Joyner, M. J., Karatsoreos, I., Kern, P. A., Klein, S., Morris, C. J., Pack, A. I., Panda, S., Ptacek, L. J., Punjabi, N. M., Sassone-Corsi, P., Scheer, F. A., Saxena, R., Seaquest, E. R., Thimgan, M. S., Van Cauter, E., Wright, K. P. (2015) Impact of sleep and circadian disruption on energy balance and diabetes: a summary of workshop discussions. Sleep. 38:1849-60.

Abbondante, S., Eckel-Mahan, K. L., Ceglia, N. J., Baldi, P., Sassone-Corsi, P. (2015) Comparative circadian metabolomics reveal differential effects of nutritional challenge in the serum and liver. J Biol Chem. 291:2812-28.

2016

Orozco-Solis, R., Aguilar-Arnal, L., Murakami, M., Peruquetti, R., Ramadori, G., Coppari, R., Sassone-Corsi, P. (2016) The circadian clock in the ventromedial hypothalamus controls cyclic energy expenditure. Cell Metab. 23:467-78.

Masri, S., Papagiannakopoulos, T., Kinouchi, K., Liu, Y., Cervantes, M., Baldi, P., Jacks, T., Sassone-Corsi, P. (2016) Lung adenocarcinoma distally rewires hepatic circadian homeostasis. Cell. 165:896-909.

Agostinelli, F., Ceglia, N., Shahbaba, B., Sassone-Corsi, P., Baldi, P. (2016) What time is it? Deep learning approaches for circadian rhythms. Bioinformatics. 32:i8-i17.

Murakami, M., Tognini, P., Liu, Y., Eckel-Mahan, K. L., Baldi, P., Sassone-Corsi, P. (2016) Gut microbiota directs PPARγ-driven reprogramming of the liver circadian clock by nutritional challenge. EMBO Rep. 17:1292-303.

Bellet, M. M., Masri, S., Astarita, G., Sassone-Corsi, P., Della Fazia, M. A., Servillo, G. (2016) Histone deacetylase SIRT1 controls proliferation, circadian rhythm, and lipid metabolism during liver regeneration in mice. J. Biol. Chem. 291:23318-23329.

Aguilar-Arnal, L., Ranjit, S., Stringari, C., Orozco-Solis, R., Gratton, E., Sassone-Corsi, P. (2016) Spatial dynamics of SIRT1 and the subnuclear distribution of NADH species. Proc Natl Acad Sci USA. 113:12715-12720.

Berger, S. L. and Sassone-Corsi, P. (2016) Metabolic signaling to chromatin. Cold Spring Harb Perspect Biol. 8(11). pii: a019463.

Kharkwal*, G., Brami-Cherrier*, K., Lizardi-Ortiz, J. E., Nelson, A. B., Ramos, M., Del Barrio, D., Sulzer, D., Kreitzer, A. C., Borrelli, E. Parkinsonism driven by antipsychotics originates from dopaminergic control of striatal cholinergic interneurons. Neuron (2016) 91 (1):67-78.

Kharkwal*,G., Radl*,D., Lewis, R., Borrelli, E. Dopamine D2 Receptors in Striatal Output Neurons Enable the Psychomotor Effects of Cocaine. Proc Natl Acad Sci USA (2016) 113:11609-11614.

Urs, N. M., Gee, S. M., Pack, T. F., McCorvy, J. D., Evron, T., Snyder, J. C., Yang, X., Rodriguiz, R. M., Borrelli, E., Wetsel, W. C., Jin, J., Roth, B.L., O’Donnell, P., Caron, M.G. Distinct cortico-striatal actions of β-arrestin-biased dopamine D2 receptor signaling reveal determinants of in vivo functional selectivity. Proc Natl Acad Sci USA (2016) 113(50):E8178-E8186.

2017

Rose, S.J., Pack, T. F., Peterson S. M., Payne, K., Borrelli, E. Caron, M.G. Engineered D2R variants reveal the balanced and biased contributions of G-protein and β-arrestin to dopamine-dependent functions. Neuropsychopharmacology (2017) doi:10.1038/npp.2017.254.

Robinson B.G., Condon A.F., Radl D., Borrelli E., Williams J.T., Neve K.A. Cocaine-induced adaptation of dopamine D2S, but not D2L autoreceptors. Elife (2017) 6. pii: e31924. doi:10.7554/eLife.31924

Orozco-Solis, R., Montellier, E., Aguilar-Arnal, L., Sato, S., Vawter, M. P., Bunney, B. G., Bunney, W. E., Sassone-Corsi, P. (2017) A circadian genomic signature common to ketamine and sleep deprivation in the anterior cingulate cortex. Biol Psychiatry.82:351-360.

Li, M., Borrelli, E., Magistretti, P. J., Izpisua Belmonte, J. C., Sassone-Corsi, P.,Orlando, V. (2017) Gathering by the Red Sea highlights links between environment and epigenetics. Nat. Struct. Mol. Biol. 24:491-493.

Tognini, P., Thaiss, C. A., Elinav, E., Sassone-Corsi, P. (2017) Circadian coordination of antimicrobial responses. Cell Host Microbe. 22:185-192. Review.

Sato, S., Solanas, G., Peixoto, F. O., Bee, L., Symeonidi, A., Schmidt, M. S., Brenner, C., Masri, S., Benitah, S. A., Sassone-Corsi, P. (2017) Circadian reprogramming in the liver identifies metabolic pathways of aging. Cell. 170:664-677.

Solanas, G., Peixoto, F. O., Perdiguero, E., Jardí, M., Ruiz-Bonilla, V., Datta, D., Symeonidi, A., Castellanos, A., Welz, P. S., Caballero, J. M., Sassone-Corsi, P., Muñoz-Cánoves, P., Benitah, S. A. (2017) Aged stem cells reprogram their daily rhythmic functions to adapt to stress. Cell. 170:678-692.

Tognini, P., Murakami, M., Liu, Y., Eckel-Mahan, K. L., Newman, J., Verdin, E., Baldi, P., Sassone-Corsi, P. (2017) Distinct circadian signatures in liver and gut clocks revealed by ketogenic diet. Cell Metabolism. 26:523-538.

Hughes, M. E., Abruzzi, K. C., Allada, R., Anafi, R., Arpat, A. B., Asher, G., Baldi, P., de Bekker, C., Bell-Pedersen, D., Blau, J., Brown, S., Ceriani, M. F., Chen, Z., Chiu, J. C., Cox, J., Crowell, A. M., DeBruyne, J. P., Dijk, D. J., DiTacchio, L., Doyle, F. J., Duffield, G. E., Dunlap, J. C., Eckel-Mahan, K., Esser, K. A., FitzGerald, G. A., Forger, D. B., Francey, L. J., Fu, Y. H., Gachon, F., Gatfield, D., de Goede, P., Golden, S. S., Green, C., Harer, J., Harmer, S., Haspel, J., Hastings, M. H., Herzel, H., Herzog, E. D., Hoffmann, C., Hong, C., Hughey, J. J., Hurley, J. M., de la Iglesia, H. O., Johnson, C., Kay, S. A., Koike, N., Kornacker, K., Kramer, A., Lamia, K., Leise, T., Lewis, S. A., Li, J., Li, X., Liu, A. C., Loros, J. J., Martino, T. A., Menet, J. S., Merrow, M., Millar, A. J., Mockler, T., Naef, F., Nagoshi, E., Nitabach, M. N., Olmedo, M., Nusinow, D. A., Ptáček, L. J., Rand, D., Reddy, A. B., Robles, M. S., Roenneberg, T., Rosbash, M., Ruben, M. D., Rund, S., Sancar, A., Sassone-Corsi, P., Sehgal, A., Sherrill-Mix, S., Skene, D. J., Storch, K. F., Takahashi, J. S., Ueda, H. R., Wang, H., Weitz, C., Westermark, P. O., Wijnen, H., Xu, Y., Wu, G., Yoo, S. H., Young, M., Zhang, E. E., Zielinski, T., Hogenesch, J. B. (2017) Guidelines for genome-scale analysis of biological rhythms. Journal of Biological Rhythms. 32(5), 380-393.

2018

Radl, D., Chiacchiaretta, M., Lewis, R.G., Brami-Cherrier, K., Arcuri, L., Borrelli, E. Differential   regulation of striatal motor behavior and related cellular responses by dopamine D2L and D2S isoforms. Proc Natl Acad Sci USA (2018) 115:198-203.

Scheggia D, Mastrogiacomo R, Mereu M, Sannino S, Straub RE, Armando M, Managò F, Guadagna S, Piras F, Zhang F, Kleinman JE, Hyde TM, Kaalund SS, Pontillo M, Orso G, Caltagirone C, Borrelli E, De Luca MA, Vicari S, Weinberger DR, Spalletta G, Papaleo F. Variation in Dysbindin-1 are associated with cognitive response to antipsychotic drug treatment. Nat. Comm. (2018) 9:2265

Dyar KA, Lutter D, Artati A, Ceglia NJ, Liu Y, Armenta D, Jastroch M, Schneider S, de Mateo S, Cervantes M, Abbondante S, Tognini P, Orozco-Solis R, Kinouchi K, Wang C, Swerdloff R, Nadeef S, Masri S, Magistretti P, Orlando V, Borrelli E, Uhlenhaut NH, Baldi P, Adamski J, Tschöp MH, Eckel-Mahan K, Sassone-Corsi P. Atlas of Circadian Metabolism reveals system-wide coordination and communication between clocks. Cell (2018) 174:1571-1585.

Gaucher, J., Montellier, E. and Sassone-Corsi, P. (2018) Molecular Cogs: Interplay between circadian clock and cell cycle. Trends Cell Biology. 28(5):368-379.

Kramer, A., Panda, S., Masri, S., Benitah, S.A., Takahashi, J.S. and Sassone-Corsi, P. (2018) Hallmarks of the mammalian circadian clock. Cell (in press)

Kinouchi, L., Magnan, C., Ceglia, N., Liu, Y., Cervantes, M., Pastore, N., Huynh, T., Ballabio, A., Baldi, P., Masri, S., Sassone-Corsi, P. (2018) Fasting imparts a switch to alternative daily pathways in liver and muscle. Cell Rep. 25(12):3299-3314.

Masri, S., and Sassone-Corsi, P. (2018) The emerging link between cancer, metabolism, and circadian rhythms. Nature Medicine. 24(12)1795-1803.

Kawamura, G., Hattori, M., Takamatsu, K., Tsukada, T., Ninomiya, Y., Benjamin, I., Sassone-Corsi, P.,Ozawa, T., & Tamaru, T. (2018) Cooperative interaction among BMAL1, HSF1, and p53 protects mammalian cells from UV stress. Communications Biology.

Sato, S., Parr, E. B., Devlin, B. L., Hawley, J. A., & Sassone-Corsi, P. (2018) Human metabolomics reveal daily variations under nutritional challenges specific to serum and skeletal muscle. Molecular Metabolism, 16, 1-11.

Dyar, K.A., Lutter, D., Artati, A., Ceglia, N., Liu, Y., Armenta, D., Jastroch, M., Schneider, S., Mateo, S.D., Cervantes, M., Abbondante, S., Tognini, P., Orozco-Solís, R., Kinouchi, K., Wang, C., Swerdloff, R.S., Nadeef, S., Masri, S.M., Magistretti, P.J., Orlando, V., Borrelli, E., Uhlenhaut, N.H., Baldi, P., Adamski, J., Tschöp, M.H., Eckel-Mahan, K., & Sassone-Corsi, P. (2018) Atlas of circadian metabolism reveals system-wide coordination and communication between clocks. Cell, 174, 1571-1585.e11.

Kwapis, JL., Alaghband, Y., Kramar, E.A., Lopez, A.J., Vogel Ciernia, A., White, A.O., Shu, G., Rhee, D., Michael, C.M., Montellier, E., Liu, Y., Magnan, C.N., Chen, S., Sassone-Corsi, P.,Baldi, P., Matheos, D.P., Wood, M.A. (2018) Epigenetic regulation of the circadian gene Per1 contributes to age-related changes in hippocampal memory. Nature Comm. 9(1):3323.

Ceglia, N., Liu, Y., Chen, S., Agostinelli, F., Eckel-Mahan, K., Sassone-Corsi, P., Baldi, P. (2018) CircadiOmics: Circadan omic web portal. Nucleic Acids Research. 46(W1)W157-W162.

Tognini, P., Murakami, M., Sassone-Corsi, P. (2018) Interplay between microbes and the circadian clock. Cold Spring Harbor. 10(9).

2019

Greco, C.M., and Sassone-Corsi, P. (2019) Circadian blueprint of metabolic pathways in the brain. Nature Reviews Neuroscience. 20(2):71-82.

Koronowski, K.B., Kinouchi, K., Welz, P.S., Smith, J.G., Zinna, V.W., Shi, J., Samad, M. Chen, S., Magnan, C.N., Kinchen, J.M., Li, W., Baldi, P., Benitah, S.A., Sassone-Corsi, P.(2019) Defining the independence of the liver circadian clock. Cell. 177(6)1462-1448.

Welz, P.S., Zinna, V.M., Symeonidi, A., Koronowski, K.B., Kinouchi, K., Smith, J.G., Guillén, I.M., Castellanos, A., Crainiciuc, G., Prats, N., Caballero, J.M., Hidalgo, A., Sassone-Corsi, P., Benitah, S.A. (2019) BMAL1-driven tissue clocks respond independently to light to maintain homeostasis. Cell. 177(6):1436-1447.

Pastore, N., Vainshtein, A., Herz, N.J., Huynh, T., Brunetti, L., Klisch, T.J., Mutarelli, M., Annunziata, P., Kinouchi, K., Brunetti-Pierri, N., Sassone-Corsi, P., Ballabio, A. (2019) Nutrient-sensitive transcription factors TFEB and TFE3 couple autophagy and metabolism to the peripheral clock. EMBO J.38(12).

Aras, E., Ramadori, G., Kinouchi, K. Liu, Y., Lorios, R.M., Brenachot, X., Ljubicic, S., Veyrat-Durebex, C., Mannucci, S., Gailé, M., Baldi, P., Sassone-Corsi, P., Coppari, R. (2019) Light entrains diurnal changes in insulin sensitivity of skeletal muscle via ventromedial hypothalamic neurons. Cell Rep. 27(8)2385-2398.

Sato, S., Basse, A.L., Schonke, M., Chen, S., Samad, M., Altintas, A., Laker, R.C., Dalbram, E., Barrés, R., Balid, P., Treeback, J.T., Zierath, J.R., Sassone-Corsi, P.(2019) Time of exercise specifies the impact on muscle metabolic pathways and systemic energy homeostasis. Cell Metabolism. 30(1):92-110.

Cervantes, M., Sassone-Corsi, P. (2019) Modification of histone proteins by serotonin in the nucleus. Nature. 567(7749):464-465.

Koronowski, K., Sassone-Corsi, P. (2019) Communicating clocks, relevance to physiology and metabolism. Science(in press)


Atlas of Circadian Metabolism Reveals System-wide Coordination and Communication between Clocks (2018). Cell 174: 1571-1585

Dyar, Lutter, Artati, Ceglia, Liu, Armenta, Jastroch, Schneider, de Mateo, Cervantes, Abbondate, Tognini, Orozco-Solis, Kinouchi, Wang, Swedloff, Nadeef, Masri, Magistretti, Orlando, Borrelli, Uhlenhaut, Baldi, Adamski, Tschop, Eckel-Mahan, and Sassone-Corsi

Metabolic diseases are often characterized by circadian misalignment in different tissues, yet how altered coordination and communication among tissue clocks relate to specific pathogenic mechanisms remains largely unknown. Applying an integrated systems biology approach, we performed 24-hr metabolomics profiling of eight mouse tissues simultaneously.


Defining the Independence of the Liver Circadian Clock (2019)Cell 177: 1448-1462

Koronowski, Kinouchi, Welz, Smith, Zinnam Shi, Samad, Chen, Magnan, Kinchen, Li, Baldi, Benitah, and Sassone-Corsi

An autonomous branch of the liver circadian clock is independent from all other clocks yet still dependent on the light-dark cycle.


BMAL1-Driven Tissue Clocks Respond Independently to Light to Maintain Homeostasis (2019)Cell 177: 1436-1447

Well, Inna, Symeonidi, Koronowski, Kinouchi, Smith, Guillén, Castellanos, Crainicius, Prats, Caballero, Hidalgo, Sassone-Corsi, and Benitah

We show that unexpectedly, light synchronizes the Bmal1-dependent circadian machinery in single tissues in the absence of Bmal1 in all other tissues. Strikingly, light-driven tissue autonomous clocks occur without rhythmic feeding behavior and are lost in constant darkness. Importantly, tissue-autonomous Bmal1 partially sustains homeostasis in otherwise arrhythmic and prematurely aging animals.


Nutrient-Sensitive Transcription Factors TFFEB and TFE3 Couple Autophagy and Metabolism to the Peripheral Clock (2019)EMBO J 38

Pastore, Vainshtein, Herz, Huynh, Brunetti, Klisch, Mutarelli, Annunziata, Kinouchi, Brunetti-Pierri, Sassone-Corsi, and Ballabio

Autophagy and energy metabolism are known to follow a circadian pattern. However, it is unclear whether autophagy and the circadian clock are coordinated by common control mechanisms. Here, we show that the oscillation of autophagy genes is dependent on the nutrient‐sensitive activation of TFEB and TFE3, key regulators of autophagy, lysosomal biogenesis, and cell homeostasis. 


Light Entrains Diurnal Changes in Insulin Sensitivity of Skeletal Muscle Via Ventromedial Hypothalamic Neurons (2019)Cell Reports 27: 2385-2398

Aras, Ramadori, Kinouchi, Liu, Loris, Brenachot, Ljubicic, Veyrat-Durebex, Mannucci, Gailé, Balid, Sassone-Corsi, and Coppari

Loss of synchrony between geophysical time and insulin action predisposes to metabolic diseases. Yet the brain and peripheral pathways linking proper insulin effect to diurnal changes in light-dark and feeding-fasting inputs are poorly understood. Here, we show that the insulin sensitivity of several metabolically relevant tissues fluctuates during the 24 hour period.


Time of Exercise Specifies the Impact on Muscle Metabolic Pathways and Systemic Energy Homeostasis (2019)Cell Metabolism 30: 92-110

Distinct response of metabolic cycles in skeletal muscle to time-of-day exercise. Early active phase exercise exerts a robust metabolic response in skeletal muscle. The metabolic response includes glycolysis, lipid oxidation, and BCAA breakdown. Time of exercise specifies the activation of HIF1α and systemic energy expenditure.

Sato, Basse, Schonke, Chen, Samad, Altintas, Laker, Dalbram, Barres, Baldi, Treebak, Zierath, and Sassone-Corsi


Modification of Histone Proteins by Serotonin in the Nucleus(2019)Nature 567: 464-465

Cervantes and Sassone-Corsi

The function of histone proteins can be modified through addition or removal of certain chemical groups. The addition of a serotonin molecule is a newly found histone modification that could influence gene expression.


Circadian Blueprint of Metabolic Pathways in the Brain(2019)Nature Reviews Neuroscience 20: 71-82

Greco and Sassone-Corsi

The circadian clock is an endogenous, time-tracking system that directs multiple metabolic and physiological functions required for homeostasis. The master or central clock located within the suprachiasmatic nucleus in the hypothalamus governs peripheral clocks present in all systemic tissues, contributing to their alignment and ultimately to temporal coordination of physiology. Accumulating evidence reveals the presence of additional clocks in the brain and suggests the possibility that circadian circuits may feed back to these from the periphery. Here, we highlight recent advances in the communications between clocks and discuss how they relate to circadian physiology and metabolism.


Fasting Imparts a Switch to Alternative Daily Pathways in Liver and Muscle(2018). Cell Reports 25: 3299-3314

Kinouchi, Magnan, Ceglia, Liu, Cervantes, Pastore, Huynh, Ballabio, Baldi, Masri, and Sassone-Corsi

The circadian clock operates as intrinsic time-keeping machinery to preserve homeostasis in response to the changing environment. While food is a known zeitgeber for clocks in peripheral tissues, it remains unclear how lack of food influences clock function. We demonstrate that the transcriptional response to fasting operates through molecular mechanisms that are distinct from time-restricted feeding regimens.


The Emerging Link between Cancer, Metabolism and Circadian Rhythms(2018). Nat Med. 24(12): 1795-1803

Masri and Sassone-Corsi

The circadian clock is a complex cellular mechanism that, through the control of diverse metabolic and gene expression pathways, governs a large array of cyclic physiological processes. Epidemiological and clinical data reveal a connection between the disruption of circadian rhythms and cancer that is supported by recent preclinical data. In addition, the use of animal models and molecular studies indicate emerging links between cancer metabolism and the circadian clock. This has implications for therapeutic approaches and we discuss the possible design of chrono-pharmacological strategies.