PAOLO SASSONE-CORSI

During the past three decades, my research has focused on the molecular mechanisms of transcriptional regulation and chromatin remodeling, specifically in response to changes in signaling transduction and cellular metabolism. In the past twenty years, we have uncovered the specific role of transcriptional and epigenetic regulators in circadian clock function and deciphered how metabolic circuits intimately connect to the circadian system. Our studies have significantly impacted the fields of transcription, epigenetics, metabolism and endocrinology.

Our expertise covers molecular, cellular, physiological and behavioral analysis of circadian rhythms in mammals, including genomics, metabolomics high-throughput profiling and Biocomputing. The high impact of our research is witnessed by the numerous high-profile publications, invitations as plenary speaker at high-profile conferences and by an h-index of 120. We have revealed how nutritional challenges reprogram circadian homeostasis (Cell 155:1464-78; Cell 161: 84-92), explored the molecular mechanisms that involve the NAD+-dependent sirtuin class of deacetylases (Cell 158: 659-72; Nat. Struct. Mol. Biol. 22: 312-18) and most recently revealed previously unforeseen pathways of circadian control that connect to nutrition, cancer and aging (Cell Metab. 23: 467-78 [2016]; Cell 165: 896-909 [2016]; Cell Metab. 26: 523-538 [2017]; Cell 170: 664-677 [2017]). These studies provide new leads towards therapeutic strategies for metabolic disorders.

Honors and Awards

1977. Philips European Award for Young Investigators
1990. Member of the European Molecular Biology Organization
1994. EMBO Gold Medal
1996. Rosen Prize (Fondation de la Recherche Médicale), France
1997. Grand Prix Liliane Bettencourt pour la Recherche, France
2001. Segerfalk Award Lecture, Lund University, Sweden
2003.  Grand Prix Charles-Léopold Mayer de l’Académie des Sciences, France
2003.  ISI Highly Cited
2004.  Edwin B. Astwood Award Lecture of The Endocrine Society, USA
2004. The Umesono Memorial Award Lecture, The Salk Institute, San Diego, USA
2004. CNRS Silver Medal, France
2006. Distinguished Professor Medal, University of California, Irvine, USA
2010. The Athalie Clarke Achievement Award, University of California, Irvine; School of Medicine, USA
2011. Roy O. Greep Award Lecture, 2011 Laureate Award by The Endocrine Society, USA
2011. The Ipsen Award in Endocrinology, France
2011. External Member, Max Planck Society, Germany
2012. Transatlantic Medal of The Society for Endocrinology, UK
2013. Dr. Henry Friesen Plenary Lecture Award, Canada
2014. Fellow, American Association for the Advancement of Science, USA
2015.  August and Marie Krogh Medal, Denmark
2016. Leonardo da Vinci Gold Medal, FMSI Federation, Rome, Italy
2017. Albert Hogan Memorial Award Lecture, University of Missouri
2018. Academic Senate Distinguished Faculty Award for Research



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Metabolon